SCHEMBL2468002

SCHEMBL2468002

O=C(O)N(CCCN1CCOCC1)c1cccc(Cn2nc(-c3cc(F)cc(F)c3)ccc2=O)c1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MET P08581 18/20 0.65
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2471207 0.95 MET (0.62) METTSHR
SCHEMBL2467442 0.94 MET (0.56) METTSHR
SCHEMBL2466179 0.93 MET (0.56) METTSHR
SCHEMBL2469731 0.93 MET (0.54) METTSHR
SCHEMBL1953412 0.91 MET (0.53) MET
SCHEMBL2470606 0.91 MET (0.53) METTSHR
SCHEMBL2469754 0.90 MET (0.52) METTSHR
SCHEMBL2466850 0.90 MET (0.52) METTSHR
SCHEMBL2472186 0.89 MET (0.52) MET
SCHEMBL2471696 0.88 MET (0.51) METTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173653-B2 Pyridiazinone derivatives for the treatment of tumours MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2012-05-08 US claimed
EP-1960370-B1 PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT MERCK PATENT GMBH (DE) 2011-10-05 EP claimed