SCHEMBL24674901

SCHEMBL24674901

OCCOCCOCCCCCCOCc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.51
TDP1 Q9NUW8 1/20 0.51
TSHR P16473 1/20 0.50
UGCG Q16739 5/20 0.48
GBA2 Q9HCG7 5/20 0.48
GBA1 P04062 4/20 0.48
NAAA Q02083 1/20 0.47
ADRB2 P07550 2/20 0.47
ADRB1 P08588 2/20 0.47
ADRB3 P13945 2/20 0.47
MEN1 O00255 1/20 0.47
THRB P10828 1/20 0.47
HTT P42858 1/20 0.47
KMT2A Q03164 1/20 0.47
MAPT P10636 1/20 0.47
EPHX2 P34913 3/20 0.46
KDM4E B2RXH2 1/20 0.43
POLB P06746 1/20 0.43
HRH4 Q9H3N8 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31110247 1.00 L3MBTL1 (0.51) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL2568514 0.98 L3MBTL1 (0.53) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL21405274 0.98 TSHR (0.52) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL17162054 0.98 TSHR (0.52) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL23720535 0.98 TSHR (0.52) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL20120627 0.98 L3MBTL1 (0.53) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL13909724 0.96 TSHR (0.54) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL16346320 0.94 TSHR (0.52) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL17162099 0.94 TSHR (0.52) L3MBTL1TDP1TSHRUGCGGBA2
SCHEMBL30380648 0.94 TSHR (0.52) L3MBTL1TDP1TSHRUGCGGBA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022159688-A9 DEGRADERS OF GRK2 AND USES THEREOF SONATA THERAPEUTICS, INC. (US) 2023-09-21 WO disclosed
WO-2023129564-A1 DEGRADERS OF GRK2 AND USES THEREOF CYGNAL THERAPEUTICS, INC. (US) 2023-07-06 WO disclosed
WO-2022159688-A1 DEGRADERS OF GRK2 AND USES THEREOF CYGNAL THERAPEUTICS, INC. (US) 2022-07-28 WO disclosed