Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 3/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4853459 | 1.00 | CYP2B6 (0.41) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Bicarbonate SCHEMBL8638184 | 0.98 | CYP2B6 (0.40) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Hydrogen Peroxide SCHEMBL15163598 | 0.94 | CYP2B6 (0.41) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Acetic Acid SCHEMBL2194343 | 0.93 | CYP2B6 (0.40) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Carbamic Acid SCHEMBL19873345 | 0.93 | STS (0.42) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Benzene SCHEMBL5574850 | 0.92 | CYP2B6 (0.42) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Benzene SCHEMBL9517087 | 0.92 | CYP2B6 (0.42) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Acetic Acid SCHEMBL11766141 | 0.91 | CYP2B6 (0.39) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Bicarbonate SCHEMBL28204557 | 0.91 | CA2 (0.39) | CYP2B6STSALOX5CYP1A1CYP1A2 | |
| Urea SCHEMBL28536729 | 0.91 | STS (0.43) | CYP2B6STSALOX5CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102989496-B | Catalyst for preparing 1, 1, 1, 2, 3, 3, 3-heptafluoropropane as well as preparation method and applications thereof | NANJING UNIVERSITY OF INFORMATION SCIENCE AND TECHNOLOGY (CN) | 2014-10-08 | — | — | CN | disclosed |
| CN-102989496-A | Catalyst for preparing 1, 1, 1, 2, 3, 3, 3-heptafluoropropane as well as preparation method and applications thereof | UNIV NANJING INF SCI & TECH | 2013-03-27 | — | — | CN | disclosed |
| US-8021616-B2 | Gas sensor | NGK SPARK PLUG CO., LTD. (JP) | 2011-09-20 | — | — | US | disclosed |
| US-20090214389-A1 | GAS SENSOR | NGK SPARK PLUG CO., LTD. (JP) | 2009-08-27 | — | — | US | disclosed |
| US-6070618-A | High pressure fuel injection pipe and a method of manufacturing the same | USUI KOKUSAI SANGYO KAISHA LIMITED (JP) | 2000-06-06 | — | — | US | disclosed |