Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675533 | 0.84 | ACACB (0.43) | HDAC8CA12CA1CA2CA9 | |
| SCHEMBL24675649 | 0.84 | ACACB (0.43) | HDAC8CA12CA1CA2CA9 | |
| SCHEMBL24675703 | 0.84 | HPGD (0.43) | HDAC8PLA2G4BLMNAMMP9MMP8 | |
| SCHEMBL24675709 | 0.84 | HPGD (0.43) | HDAC8PLA2G4BLMNAMMP9MMP8 | |
| Hydrochloric Acid SCHEMBL30491000 | 0.83 | PLA2G4B (0.53) | PLA2G4BLMNAMMP9MMP8MMP13 | |
| Hydrochloric Acid SCHEMBL30490834 | 0.83 | PLA2G4B (0.53) | PLA2G4BLMNAMMP9MMP8MMP13 | |
| SCHEMBL24675606 | 0.82 | SMN1; SMN2 (0.42) | PLA2G4BLMNAHDAC1HDAC2 | |
| SCHEMBL24675229 | 0.81 | LMNA (0.41) | HDAC8PLA2G4BLMNAMMP9MMP8 | |
| SCHEMBL24675711 | 0.81 | PLA2G4B (0.52) | PLA2G4BLMNAMMP9MMP8MMP13 | |
| SCHEMBL24675884 | 0.80 | ACACB (0.43) | CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |