Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675709 | 1.00 | HPGD (0.43) | HPGDGAAALDH1A1PLA2G4BLMNA | |
| SCHEMBL24675229 | 0.95 | LMNA (0.41) | HPGDGAAALDH1A1PLA2G4BLMNA | |
| SCHEMBL24675241 | 0.87 | PPARD (0.42) | GAAPLA2G4BLMNAMMP9MMP8 | |
| SCHEMBL25823404 | 0.87 | PPARD (0.42) | GAAPLA2G4BLMNAMMP9MMP8 | |
| SCHEMBL24675242 | 0.87 | PPARD (0.42) | GAAPLA2G4BLMNAMMP9MMP8 | |
| SCHEMBL24675246 | 0.85 | ALDH1A1 (0.45) | GAAALDH1A1LMNAPDE3BPDE3A | |
| SCHEMBL25828664 | 0.85 | ALDH1A1 (0.45) | GAAALDH1A1LMNAPDE3BPDE3A | |
| SCHEMBL24675591 | 0.85 | ALDH1A1 (0.45) | GAAALDH1A1LMNAPDE3BPDE3A | |
| SCHEMBL24675711 | 0.84 | PLA2G4B (0.52) | GAAPLA2G4BLMNAMMP9MMP8 | |
| SCHEMBL24675851 | 0.84 | HDAC8 (0.43) | PLA2G4BLMNAMMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |