SCHEMBL24676488

SCHEMBL24676488

Cc1nc(NC2CCC2)sc1-c1cc(NC2CCN(S(C)(=O)=O)CC2)ncc1C#N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 12/20 0.48
CCND1 P24385 11/20 0.48
CDK6 Q00534 11/20 0.48
CDK4 P11802 8/20 0.48
CCND3 P30281 6/20 0.48
CCNT1 O60563 6/20 0.48
CDK9 P50750 6/20 0.48
CDK1 P06493 5/20 0.48
CCNB1 P14635 5/20 0.48
CCNA2 P20248 4/20 0.48
CDK7 P50613 4/20 0.48
CCNH P51946 4/20 0.48
CCNE1 P24864 8/20 0.39
CCR6 P51684 2/20 0.39
TDO2 P48775 1/20 0.39
PI4KB Q9UBF8 3/20 0.39
MNAT1 P51948 1/20 0.37
CCNB2 O95067 1/20 0.37
CCNE2 O96020 1/20 0.37
CDK5 Q00535 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24676825 0.92 CCNA2 (0.43) CDK2CCND1CDK6CDK4CCND3
SCHEMBL24675990 0.86 CDK2 (0.38) CDK2CCND1CDK6CDK4CCND3
SCHEMBL29754870 0.86 CDK2 (0.38) CDK2CCND1CDK6CDK4CCND3
SCHEMBL24676487 0.86 TDO2 (0.41) CDK2CCND1CDK6CDK4CCND3
SCHEMBL24676461 0.85 CDK2 (0.59) CDK2CCND1CDK6CDK4CCND3
SCHEMBL24676692 0.84 CDK2 (0.38) CDK2CCND1CDK6CDK4CCND3
SCHEMBL24676827 0.83 CDK2 (0.42) CDK2CCND1CDK6CDK4CCND3
SCHEMBL24676829 0.81 CCNT1 (0.43) CDK2CCNT1CDK9CDK1CCNB1
SCHEMBL24676010 0.80 CCR6 (0.40) CDK2CCND1CDK6CDK4CCND3
SCHEMBL29754970 0.80 CCR6 (0.40) CDK2CCND1CDK6CDK4CCND3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022155941-A1 CDK2 INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2022-07-28 WO disclosed