SCHEMBL24676493

SCHEMBL24676493

CC(C)c1ncc(-c2nc(Cl)ncc2F)s1

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.35
ALDH1A1 P00352 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
KMT2A Q03164 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29755049 1.00 SMN1; SMN2 (0.35) SMN1; SMN2ALDH1A1L3MBTL1KMT2AMAPT
SCHEMBL24054302 0.81 ADORA2A (0.37) SMN1; SMN2ALDH1A1L3MBTL1KMT2AMAPT
SCHEMBL7253693 0.72 CYP2A6 (0.42) SMN1; SMN2ALDH1A1L3MBTL1KMT2AMAPT
SCHEMBL24322338 0.71 CCND1 (0.59)
SCHEMBL21610561 0.71 ALDH1A1 (0.31) SMN1; SMN2ALDH1A1
SCHEMBL2976971 0.70 RXRA (0.31)
SCHEMBL2984237 0.70 MAPT (0.35) SMN1; SMN2KMT2AMAPT
SCHEMBL2987501 0.69 ABL1 (0.34)
SCHEMBL12413632 0.69 SMN1; SMN2 (0.42) SMN1; SMN2ALDH1A1L3MBTL1KMT2AMAPT
SCHEMBL2971693 0.68 CASR (0.36) SMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022155941-A1 CDK2 INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2022-07-28 WO disclosed