Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | ADH5 | P11766 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24677007 | 0.84 | IDO1 (0.42) | IDO1NOTUMPRMT5WDR77CYP19A1 | |
| SCHEMBL29769795 | 0.78 | PIM1 (0.40) | IDO1ADH5CYP3A4CYP2D6MAPT | |
| SCHEMBL30833265 | 0.77 | CYP11B1 (0.55) | IDO1CYP19A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL29769805 | 0.75 | CYP1A2 (0.42) | IDO1NOTUMCYP3A4CYP2D6MAPT | |
| SCHEMBL16126788 | 0.75 | CYP11B1 (0.53) | IDO1NOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL22078064 | 0.75 | ADH5 (0.53) | IDO1ADH5CYP3A4BAZ2BTBXAS1 | |
| SCHEMBL29769796 | 0.73 | CD38 (0.47) | PRMT5WDR77PDE3BPDE3A | |
| SCHEMBL24676901 | 0.71 | CNR1 (0.47) | IDO1 | |
| SCHEMBL829894 | 0.70 | KDM4E (0.47) | IDO1MAPTLMNAALDH1A1HTT | |
| SCHEMBL22078072 | 0.70 | ADH5 (0.53) | ADH5CYP3A4BAZ2BTBXAS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117580829-A | Quinoline and azaquinolines as inhibitors of CD38 | 勃林格英格翰国际有限公司 | 2024-02-20 | — | — | CN | disclosed |
| EP-4284511-A1 | QUINOLINES AND AZAQUINOLINES AS INHIBITORS OF CD38 | Boehringer Ingelheim International GmbH (DE) | 2023-12-06 | — | — | EP | disclosed |
| WO-2022165114-A1 | QUINOLINES AND AZAQUINOLINES AS INHIBITORS OF CD38 | RIBON THERAPEUTICS, INC. (US) | 2022-08-04 | — | — | WO | disclosed |
| US-20220242862-A1 | QUINOLINES AND AZAQUINOLINES AS INHIBITORS OF CD38 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220242862-A1 | QUINOLINES AND AZAQUINOLINES AS INHIBITORS OF CD38 | CD38, NQO2, NQO1 | IDO1 1082/4885NOTUM 3869/4885ADH5 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.