Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | BRPF1 | P55201 | 5/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 6/20 | 0.45 |
| ▸ | MAOB | P27338 | 6/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24677009 | 0.77 | IDO1 (0.48) | CYP11B1CYP11B2CYP19A1IDO1CYP3A4 | |
| SCHEMBL24677007 | 0.74 | IDO1 (0.42) | CYP11B1CYP11B2CYP19A1IDO1CYP3A4 | |
| SCHEMBL28274864 | 0.73 | CYP11B1 (0.71) | CYP11B1CYP11B2CYP19A1NCOA3MAOA | |
| SCHEMBL7592308 | 0.73 | CYP11B1 (0.57) | CYP11B1CYP11B2CYP19A1NCOA3MAOA | |
| SCHEMBL2071832 | 0.72 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1NCOA3MAOA | |
| SCHEMBL4499181 | 0.70 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1NCOA3MAOA | |
| SCHEMBL16126788 | 0.70 | CYP11B1 (0.53) | CYP11B1CYP11B2CYP19A1NCOA3MAOA | |
| SCHEMBL10464389 | 0.70 | CYP19A1 (0.56) | CYP11B1CYP11B2CYP19A1NCOA3MAOA | |
| SCHEMBL29766461 | 0.69 | CD38 (0.38) | CYP11B1CYP11B2NCOA3CYP3A4 | |
| SCHEMBL20538384 | 0.69 | CYP3A4 (0.61) | CYP11B1CYP11B2CYP19A1IDO1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117580829-A | Quinoline and azaquinolines as inhibitors of CD38 | 勃林格英格翰国际有限公司 | 2024-02-20 | — | — | CN | claimed |
| CN-117580829-A | Quinoline and azaquinolines as inhibitors of CD38 | 勃林格英格翰国际有限公司 | 2024-02-20 | — | — | CN | disclosed |