Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KIF5B | P33176 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | FLT1 | P17948 | 3/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16619769 | 0.80 | FGFR1 (0.45) | RETKIF5BEGFRKDRKDM1A | |
| SCHEMBL27122680 | 0.78 | PDE4A (0.37) | L3MBTL1SMN1; SMN2ALDH1A1RETKIF5B | |
| SCHEMBL29892309 | 0.78 | PDE4A (0.37) | L3MBTL1SMN1; SMN2ALDH1A1RETKIF5B | |
| SCHEMBL5040481 | 0.77 | ESR1 (0.40) | L3MBTL1MEN1KMT2A | |
| SCHEMBL5532256 | 0.73 | SMN1; SMN2 (0.45) | L3MBTL1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL19185178 | 0.73 | PDE4A (0.50) | SMN1; SMN2RETKIF5BEGFRKDR | |
| SCHEMBL15028055 | 0.72 | KDM4E (0.41) | SMN1; SMN2ALDH1A1RETKIF5BEGFR | |
| SCHEMBL14823684 | 0.72 | SLC6A4 (0.46) | L3MBTL1SMN1; SMN2ALDH1A1KDM1AMAPT | |
| SCHEMBL29597464 | 0.70 | ALDH1A1 (0.36) | L3MBTL1SMN1; SMN2ALDH1A1KDM1AMAPT | |
| SCHEMBL14870995 | 0.70 | L3MBTL1 (0.51) | L3MBTL1SMN1; SMN2ALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022188819-A1 | SOS1 PROTEOLYSIS MODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-09-15 | — | — | WO | disclosed |