SCHEMBL2467803

SCHEMBL2467803

Nc1c(Cl)c(OC(=O)O)nc(-c2ccccc2)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
KDM4E B2RXH2 5/20 0.46
HPGD P15428 2/20 0.46
LMNA P02545 1/20 0.46
GLA P06280 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
XDH P47989 1/20 0.44
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
ADORA2A P29274 6/20 0.38
ADORA1 P30542 4/20 0.38
MEN1 O00255 1/20 0.38
HTT P42858 1/20 0.38
KMT2A Q03164 1/20 0.38
ADORA2B P29275 1/20 0.37
CYP1A2 P05177 2/20 0.36
NUDT1 P36639 1/20 0.36
MAP2K3 P46734 1/20 0.36
ALOX5 P09917 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2465144 0.90 KDM4E (0.39) ALDH1A1KDM4EHPGDLMNASMN1; SMN2
SCHEMBL2469144 0.85 PDCD1 (0.46) ALDH1A1KDM4ELMNASMN1; SMN2ADORA2A
SCHEMBL2468821 0.84 PLAU (0.41) ALDH1A1GAAPTGDR2
SCHEMBL2468828 0.79 ALDH1A1 (0.44) ALDH1A1KDM4ESMN1; SMN2POLBGAA
SCHEMBL2469147 0.78 DHODH (0.38) ALDH1A1KDM4EHPGDLMNAADORA2A
SCHEMBL2465873 0.78 DHODH (0.37) ALDH1A1KDM4EHPGDLMNASMN1; SMN2
SCHEMBL2463156 0.77 ADORA2A (0.40) ADORA2AADORA1
SCHEMBL2467801 0.76 TDP1 (0.56) ALDH1A1KDM4EHPGDLMNAGLA
SCHEMBL2466429 0.76 HSP90AB1 (0.36) ALDH1A1KDM4EHPGDSMN1; SMN2GAA
SCHEMBL2470000 0.76 ACHE (0.45) ALDH1A1KDM4EHPGDSMN1; SMN2XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed