Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | PRKCI | P41743 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | ROR1 | Q01973 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.33 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.32 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30084172 | 1.00 | AXL (0.46) | AXLPRKCIGRM5AAK1ROR1 | |
| SCHEMBL30084219 | 0.86 | AXL (0.48) | AXLPRKCIAAK1CSNK1DMAPK14 | |
| SCHEMBL24678675 | 0.86 | AXL (0.48) | AXLPRKCIAAK1CSNK1DMAPK14 | |
| SCHEMBL24678879 | 0.83 | AXL (0.47) | AXLPRKCIAAK1CSNK1DMAPK14 | |
| SCHEMBL30084217 | 0.83 | AXL (0.47) | AXLPRKCIAAK1CSNK1DMAPK14 | |
| SCHEMBL24678177 | 0.82 | AXL (0.49) | AXLPRKCIGRM5AAK1NUDT1 | |
| SCHEMBL30084244 | 0.82 | AXL (0.49) | AXLPRKCIGRM5AAK1NUDT1 | |
| SCHEMBL24678393 | 0.81 | AXL (0.55) | AXLPRKCIGRM5AAK1CSNK1D | |
| SCHEMBL24678122 | 0.81 | AXL (0.48) | AXLPRKCIAAK1CSNK1DMAPK14 | |
| SCHEMBL24678406 | 0.81 | AXL (0.48) | AXLPRKCIAAK1NUDT1TTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022247676-A1 | COMPOUND WITH DIPYRROLOPYRIDINE STRUCTURE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 南京康屹生物医药中心(有限合伙) | 2022-12-01 | — | — | WO | disclosed |
| CN-115385911-A | Compound with dipyrrolopyridine structure, preparation method and medical application | 南京康屹生物医药中心(有限合伙) | 2022-11-25 | — | — | CN | disclosed |
| CN-113292561-A | Compound with dipyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |