Sugi Predict

Sugi Predict / Compounds / SCHEMBL2468069

SCHEMBL2468069

SCHEMBL2468069

Nc1cc(-c2ccc(Cl)cc2F)nc(C(=O)O)c1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMO O15229 3/20 0.53
▸ GRM2 Q14416 3/20 0.44
▸ EIF4E P06730 1/20 0.40
▸ CDC7 O00311 1/20 0.40
▸ PLK4 O00444 1/20 0.40
▸ MAPK13 O15264 1/20 0.40
▸ DAPK3 O43293 1/20 0.40
▸ DYRK3 O43781 1/20 0.40
▸ JAK2 O60674 1/20 0.40
▸ PRKD3 O94806 1/20 0.40
▸ CHEK2 O96017 1/20 0.40
▸ PRKCG P05129 1/20 0.40
▸ CDK1 P06493 1/20 0.40
▸ PRKACA P17612 1/20 0.40
▸ CDK2 P24941 1/20 0.40
▸ MARK3 P27448 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ FRK P42685 1/20 0.40
▸ MAPK8 P45983 1/20 0.40
▸ MAPK9 P45984 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2466887 0.89 KMO (0.49) KMOGRM2EIF4ECYP3A4TDP1
SCHEMBL9938970 0.87 CYP3A4 (0.46) KMOMAPK1CYP3A4TDP1DHODH
SCHEMBL16075432 0.87 KMO (0.40) KMOGRM2CYP3A4TDP1DHODH
SCHEMBL16075455 0.87 KMO (0.40) KMOGRM2CDK9PIM3CYP3A4
SCHEMBL2464665 0.87 GRM2 (0.42) KMOGRM2CYP3A4TDP1PTGES
SCHEMBL2469709 0.86 CYP3A4 (0.40) KMOGRM2EIF4ECYP3A4GRIN2B
SCHEMBL2468344 0.86 HSP90AA1 (0.50) CYP3A4DHODHCOPS5HSP90AA1HSP90AB1
SCHEMBL2467526 0.85 ATR (0.46) EIF4EPIM3DHODH
SCHEMBL11907240 0.85 KMO (0.58) KMOGRM2EIF4ECDC7PLK4
SCHEMBL3329122 0.85 ABL1 (0.45) KMOGRM2CDC7PLK4MAPK13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020253696-A1 SUBSTITUTED PYRIDINEMETHYLENE PYRIDINECARBOXYLATE DERIVATIVE, PREPARATION METHOD THEREFOR AND HERBICIDAL COMPOSITION AND USE THEREOF 青岛清原化合物有限公司 2020-12-24 — — WO disclosed
EP-2975939-B1 BROADLEAF CROP CONTROL WITH 6-ARYLPICOLINE CARBOXYLIC ACIDS, 2-ARYLPYRIMIDINE CARBOXYLIC ACIDS, OR SALTS OR ESTERS THEREOF DOW AGROSCIENCES LLC (US) 2020-08-05 — — EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 — — EP disclosed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 — — EP disclosed
US-8962523-B2 Herbicide/safener combination BAYER CROPSCIENCE AG (DE) 2015-02-24 — — US disclosed
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2015-02-19 — — US disclosed
WO-2014158614-A1 BROADLEAF CROP CONTROL WITH 6-ARYLPICOLINE CARBOXYLIC ACIDS, 2-ARYLPYRIMIDINE CARBOXYLIC ACIDS, OR SALTS OR ESTERS THEREOF DOW AGROSCIENCES LLC (US) 2014-10-02 — — WO disclosed
US-20140274715-A1 BROADLEAF CROP CONTROL WITH 6-ARYLPICOLINE CARBOXYLIC ACIDS, 2-ARYLPYRIMIDINE CARBOXYLIC ACIDS, OR SALTS OR ESTERS THEREOF DOW AGROSCIENCES LLC (US) 2014-09-18 — — US disclosed
US-20140274715-A1 BROADLEAF CROP CONTROL WITH 6-ARYLPICOLINE CARBOXYLIC ACIDS, 2-ARYLPYRIMIDINE CARBOXYLIC ACIDS, OR SALTS OR ESTERS THEREOF DOW AGROSCIENCES LLC (US) 2014-09-18 — — US disclosed
CN-102803219-A Preparation method of 6- (aryl) -4-amino picolinate DOW AGROSCIENCES LLC 2012-11-28 — — CN disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 — — WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 — — EP disclosed
CN-101360713-A 6- (polysubstituted aryl) -4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2009-02-04 — — CN disclosed
CN-1245401-C 6-aryl-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2006-03-15 — — CN disclosed
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 — — EP disclosed
CN-1551876-A 6-aryl-4-aminopicolinates and their use as herbicides �ݶ�ũ�����޹�˾ 2004-12-01 — — CN disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 — — US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 — — EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 — — US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140274715-A1 BROADLEAF CROP CONTROL WITH 6-ARYLPICOLINE CARBOXYLIC ACIDS, 2-ARYLPYRIMIDINE CARBOXYLIC ACIDS, OR SALTS OR ESTERS THEREOF ABAT, NAT1, SLC7A5 KMO 446/4885GRM2 1021/4885EIF4E 2261/4885
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT KMO 256/4885GRM2 59/4885EIF4E 4050/4885
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 KMO 2242/4885GRM2 90/4885EIF4E 4640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.