Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 9/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247635 | 0.76 | KDR (0.43) | MET | |
| SCHEMBL251970 | 0.72 | PIK3CG (0.40) | PIK3CGMETAHRMAP3K14 | |
| SCHEMBL246806 | 0.70 | PIK3CG (0.40) | PIK3CGAHRMAP3K14 | |
| SCHEMBL31132469 | 0.69 | MET (0.47) | PIK3CGMETAHRMAP3K14 | |
| SCHEMBL19182662 | 0.69 | MET (0.48) | MET | |
| SCHEMBL3267416 | 0.68 | KCNH2 (0.41) | PDE10A | |
| SCHEMBL253221 | 0.66 | PIK3CG (0.36) | PIK3CGAHR | |
| Hydrochloric Acid SCHEMBL251752 | 0.65 | PIK3CG (0.35) | PIK3CGAHR | |
| SCHEMBL1049357 | 0.64 | MET (0.41) | METAHR | |
| SCHEMBL17681367 | 0.64 | PIM1 (0.55) | PIK3CGMETAHRMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |
| EP-2313407-A1 | cMET INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010019899-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |