Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386281 | 0.83 | PDE10A (0.50) | KCNH2PDE10AMIFTP53MAPT | |
| SCHEMBL15254727 | 0.82 | KCNH2 (0.41) | KCNH2NOS2TLR8MIFTLR7 | |
| SCHEMBL2066270 | 0.77 | PDE10A (0.37) | KCNH2NOS2PDE10AMIFTLR7 | |
| SCHEMBL20956295 | 0.77 | NOS2 (0.41) | KCNH2NOS2TLR8TLR7TP53 | |
| SCHEMBL2065574 | 0.77 | PDE10A (0.52) | KCNH2NOS2PDE10ATLR7CYP19A1 | |
| SCHEMBL2065680 | 0.77 | PDE10A (0.36) | KCNH2NOS2PDE10ATLR7TP53 | |
| SCHEMBL2066636 | 0.74 | PDE10A (0.40) | PDE10ATP53SMN1; SMN2CYP19A1 | |
| SCHEMBL963746 | 0.73 | HTR2A (0.41) | TLR8TP53MAPTSMN1; SMN2 | |
| SCHEMBL10651411 | 0.72 | KDM4E (0.46) | KCNH2MIFMAPTCYP19A1CNR1 | |
| SCHEMBL2068243 | 0.71 | PDE10A (0.53) | NOS2PDE10ATP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007099-A1 | 2-AMINOIMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2010-01-21 | — | — | WO | disclosed |