Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 12/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
| ▸ | F3 | P13726 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914596 | 0.88 | PARP10 (0.35) | HSP90AA1HSP90AB1PARP10PARP11PARP1 | |
| SCHEMBL27157750 | 0.85 | ROCK1 (0.36) | HSP90AA1HSP90AB1PARP10PARP11PARP1 | |
| SCHEMBL22491231 | 0.83 | CSF1R (0.35) | HSP90AA1HSP90AB1PARP10PARP11PARP1 | |
| SCHEMBL7166501 | 0.83 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1PARP10PARP11PARP1 | |
| SCHEMBL28654934 | 0.80 | LPL (0.33) | — | |
| SCHEMBL29123417 | 0.78 | CA12 (0.33) | HSP90AA1HSP90AB1 | |
| SCHEMBL30720809 | 0.77 | PARP10 (0.54) | PARP10PARP11PARP1KDM4EGRM5 | |
| SCHEMBL1636716 | 0.77 | PARP10 (0.54) | PARP10PARP11PARP1KDM4EGRM5 | |
| SCHEMBL23162343 | 0.75 | CSF1R (0.31) | — | |
| SCHEMBL2052209 | 0.74 | PARP10 (0.54) | PARP10PARP11PARP1KDM4EF7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |