Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD4 | P21917 | 3/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914505 | 1.00 | DRD3 (0.58) | DRD3DRD2DRD4AKR1C3HDAC1 | |
| SCHEMBL24680998 | 1.00 | DRD3 (0.58) | DRD3DRD2DRD4AKR1C3HDAC1 | |
| SCHEMBL25896262 | 0.85 | DRD3 (0.44) | DRD3DRD2DRD4AKR1C3HDAC1 | |
| SCHEMBL25890140 | 0.81 | DRD3 (0.41) | DRD3DRD2DRD4SLC6A3PIK3CD | |
| SCHEMBL24681132 | 0.81 | DRD3 (0.51) | DRD3DRD2DRD4AKR1C3HDAC1 | |
| SCHEMBL30040996 | 0.81 | DRD3 (0.51) | DRD3DRD2DRD4AKR1C3HDAC1 | |
| SCHEMBL24681312 | 0.81 | DRD3 (0.54) | DRD3DRD2DRD4AKR1C3HDAC1 | |
| SCHEMBL5493423 | 0.78 | DRD3 (0.55) | DRD3DRD2DRD4AKR1C3HDAC1 | |
| SCHEMBL5497644 | 0.76 | DRD3 (0.58) | DRD3DRD2DRD4AKR1C3HDAC1 | |
| SCHEMBL24680837 | 0.76 | HSD11B1 (0.53) | DRD3DRD2DRD4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |