SCHEMBL2468355

SCHEMBL2468355

CCOc1cc(-c2cc(N)c(Cl)c(OC(=O)OC)n2)c(F)cc1Cl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK9 P45984 3/20 0.36
MAPK8 P45983 2/20 0.36
MAPK10 P53779 2/20 0.36
MAPK1 P28482 2/20 0.36
PRKD2 Q9BZL6 2/20 0.36
PRKD3 O94806 1/20 0.36
FRK P42685 1/20 0.35
CSF1R P07333 1/20 0.35
CSNK1D P48730 1/20 0.35
RORC P51449 1/20 0.35
PPOX P50336 1/20 0.35
SGK1 O00141 1/20 0.34
MTNR1A P48039 2/20 0.33
MTNR1B P49286 2/20 0.33
STING1 Q86WV6 1/20 0.33
AGPAT2 O15120 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
AAK1 Q2M2I8 1/20 0.33
EGFR P00533 1/20 0.32
ALPL P05186 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2465963 0.90 MAPK9 (0.35) MAPK9MAPK8MAPK10MAPK1PRKD2
SCHEMBL2467937 0.89 HSP90AA1 (0.40) MTNR1AMTNR1BHSP90AB1
SCHEMBL17797226 0.86 RET (0.35) MAPK9MAPK8MAPK10MAPK1PRKD2
SCHEMBL2462793 0.84 PDCD1LG2 (0.35) MAPK9MAPK8MAPK10FRKALPL
SCHEMBL3327911 0.83 S1PR4 (0.36) MAPK9MAPK8MAPK10MAPK1PRKD2
SCHEMBL2465634 0.82 MAPK9 (0.38) MAPK9MAPK8MAPK10MAPK1PRKD2
SCHEMBL2466895 0.82 MAPK9 (0.38) MAPK9MAPK8MAPK10MAPK1PRKD2
SCHEMBL2470470 0.81 NQO2 (0.31)
SCHEMBL2465961 0.81 STING1 (0.35) MAPK9MAPK8MAPK10MAPK1PRKD2
SCHEMBL2464677 0.81 LMNA (0.35) MAPK9MAPK8MAPK10MAPK1PRKD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP claimed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed