Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12215290 | 0.85 | NPC1 (0.74) | LMNAMAPK14NPC1SMN1; SMN2HTT | |
| SCHEMBL29982783 | 0.84 | TSHR (0.54) | LMNASMN1; SMN2CYP3A4ALDH1A1MAPT | |
| SCHEMBL13932522 | 0.83 | ALDH1A1 (0.78) | LMNAMAPK14SMN1; SMN2HTTMMP13 | |
| SCHEMBL24690189 | 0.81 | MTNR1A (0.55) | LMNASMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL13947386 | 0.81 | ALDH1A1 (0.66) | LMNAMAPK14NPC1SMN1; SMN2HTT | |
| SCHEMBL26601296 | 0.80 | TSHR (0.50) | LMNASMN1; SMN2CYP3A4ALDH1A1MAPT | |
| SCHEMBL31061058 | 0.79 | MAPK14 (1.00) | LMNAMAPK14NPC1SMN1; SMN2HTT | |
| SCHEMBL7990811 | 0.79 | EPHX2 (0.67) | LMNAMAPK14NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7986010 | 0.79 | PRSS1 (0.63) | LMNASMN1; SMN2EPHX2NR1H4 | |
| SCHEMBL9416606 | 0.79 | NPC1 (0.82) | MAPK14NPC1SMN1; SMN2ALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022224212-A1 | GPR35 AGONIST COMPOUNDS | HEPTARES THERAPEUTICS LIMITED (GB) | 2022-10-27 | — | — | WO | disclosed |