Rebeccamycin

Rebeccamycin

SCHEMBL24695

CO[C@H]1[C@H](O)[C@@H](O)[C@H](n2c3c(Cl)cccc3c3c4c(c5c6cccc(Cl)c6[nH]c5c32)C(=O)NC4=O)O[C@@H]1CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 1.00
PAX8 Q06710 1/20 1.00
PRKCA P17252 10/20 0.84
PRKD3 O94806 1/20 0.80
PRKCG P05129 1/20 0.80
PRKCB P05771 1/20 0.80
PRKCH P24723 1/20 0.80
PRKCI P41743 1/20 0.80
PRKCE Q02156 1/20 0.80
PRKCQ Q04759 1/20 0.80
PRKCZ Q05513 1/20 0.80
PRKCD Q05655 1/20 0.80
PRKD1 Q15139 1/20 0.80
TOP1 P11387 12/20 0.62
EGFR P00533 3/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rebeccamycin SCHEMBL12961242 1.00 DYRK1A (1.00) DYRK1APAX8PRKCAPRKD3PRKCG
Rebeccamycin SCHEMBL32690193 1.00 DYRK1A (1.00) DYRK1APAX8PRKCAPRKD3PRKCG
Rebeccamycin SCHEMBL14069957 1.00 DYRK1A (1.00) DYRK1APAX8PRKCAPRKD3PRKCG
Rebeccamycin SCHEMBL30194716 1.00 DYRK1A (1.00) DYRK1APAX8PRKCAPRKD3PRKCG
SCHEMBL10027492 0.89 DYRK1A (0.81) DYRK1APAX8PRKCAPRKD3PRKCG
SCHEMBL7165791 0.86 DYRK1A (0.76) DYRK1APAX8PRKCAPRKD3PRKCG
Rebeccamycin SCHEMBL19100060 0.86 DYRK1A (0.75) DYRK1APAX8PRKCAPRKD3PRKCG
Becatecarin SCHEMBL5953787 0.85 PRKCA (0.78) DYRK1APAX8PRKCAPRKD3PRKCG
Becatecarin SCHEMBL5953888 0.85 PRKCA (0.78) DYRK1APAX8PRKCAPRKD3PRKCG
Becatecarin SCHEMBL31237559 0.85 PRKCA (0.78) DYRK1APAX8PRKCAPRKD3PRKCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6055 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731263-A1 BIO-CONJUGATES FOR ONCOLOGY RDP Pharma AG (CH) 2026-04-29 EP claimed
EP-4673458-A1 METHODS OF ENHANCING PRODUCTION OF METABOLITES IN BACTERIA JOHN INNES CENTRE (GB) 2026-01-07 EP claimed
US-20250325717-A1 ANTI-NUCLEOPHOSMIN 1 ANTIBODY AND ANTIBODY CONJUGATE COMBINATION THERAPIES THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-23 US claimed
US-20250313647-A1 MUTANT AND MISLOCALIZED CELL SURFACE NUCLEOPHOSMIN 1 AS A DIAGNOSTIC AND THERAPEUTIC TARGET OF HUMAN DISEASE THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-09 US claimed
US-20250304688-A1 Methods and Compositions Comprising Anti-CD3 Antibodies and DYRK1A Inhibitors for Treating Diabetes PROVENTION BIO, INC. (US) 2025-10-02 US claimed
US-20250275946-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2025-09-04 US claimed
EP-4580677-A2 SARS-COV2 ANTIBODIES AND USES THEREOF Invivyd, Inc. (US) 2025-07-09 EP claimed
EP-4514857-A2 ANTI-NUCLEOPHOSMIN 1 ANTIBODY AND ANTIBODY CONJUGATE COMBINATION THERAPIES The Children's Medical Center Corporation (US) 2025-03-05 EP claimed
EP-4514858-A2 MUTANT AND MISLOCALIZED CELL SURFACE NUCLEOPHOSMIN 1 AS A DIAGNOSTIC AND THERAPEUTIC TARGET OF HUMAN DISEASE The Children's Medical Center Corporation (US) 2025-03-05 EP claimed
EP-4505179-A2 SARS-COV2 ANTIBODIES AND USES THEREOF Invivyd, Inc. (US) 2025-02-12 EP claimed
US-5468849-A Rebeccamycin analogs by tryptophan analogs feeding BRISTOL-MYERS SQUIBB COMPANY (US) 1995-11-21 US claimed
EP-0269025-B1 REBECCAMYCIN ANALOGS Bristol-Myers Squibb Company (US) 1993-01-13 EP claimed
EP-0450327-A1 Biosynthesis of rebeccamycin analogs by tryptophan analogs feeding Bristol-Myers Squibb Company (US) 1991-10-09 EP claimed
EP-0445736-A1 Rebeccamycin analog and pharmaceutical composition containing it Bristol-Myers Squibb Company (US) 1991-09-11 EP claimed
CN-1047204-A Stabilizing solution of rebeccamycin analog and preparation method thereof BRISTOL MYERS SQUIBB CO (US) 1990-11-28 CN claimed
EP-0115350-B1 REBECCAMYCIN AND PROCESS FOR ITS PREPARATION Bristol-Myers Company (US) 1988-08-17 EP claimed
EP-0269025-A2 Rebeccamycin analogs Bristol-Myers Squibb Company (US) 1988-06-01 EP claimed
US-4552842-A ANTITUMOR AGENTS BRISTOL-MYERS COMPANY (US) 1985-11-12 US claimed
US-4487925-A ANTITUMOR AGENT BRISTOL-MYERS COMPANY (US) 1984-12-11 US claimed
EP-0115350-A2 Rebeccamycin and process for its preparation Bristol-Myers Company (US) 1984-08-08 EP claimed