SCHEMBL24697641

SCHEMBL24697641

N#Cc1ccc(NS(=O)(=O)c2c[nH]c(-c3ccc(F)cc3F)c2)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MOGAT2 Q3SYC2 5/20 0.44
ATIC P31939 1/20 0.43
LMNA P02545 1/20 0.43
ACLY P53396 5/20 0.40
SLC22A12 Q96S37 1/20 0.40
THRB P10828 1/20 0.38
CRBN Q96SW2 1/20 0.38
MGAT2 Q10469 4/20 0.38
KMT2A Q03164 1/20 0.38
PIK3CA P42336 1/20 0.38
MGAT3 Q09327 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31086082 1.00 MOGAT2 (0.44) MOGAT2ATICLMNAACLYSLC22A12
SCHEMBL31085749 0.96 ATIC (0.46) MOGAT2ATICLMNAACLYSLC22A12
SCHEMBL31086172 0.92 ATIC (0.44) MOGAT2ATICLMNAACLYSLC22A12
SCHEMBL31085907 0.91 ATIC (0.43) MOGAT2ATICLMNAACLYSLC22A12
SCHEMBL31086074 0.91 CRBN (0.42) MOGAT2ATICLMNAACLYSLC22A12
SCHEMBL24697648 0.89 ATIC (0.41) MOGAT2ATICACLYCRBNKMT2A
SCHEMBL31086076 0.89 ATIC (0.41) MOGAT2ATICACLYCRBNKMT2A
SCHEMBL24697651 0.89 ACLY (0.45) ATICLMNAACLYSLC22A12CRBN
SCHEMBL31085776 0.89 ACLY (0.45) ATICLMNAACLYSLC22A12CRBN
SCHEMBL31086063 0.89 ATIC (0.44) MOGAT2ATICLMNAACLYSLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022254027-A1 3-PYRROLYLSULFONAMIDE COMPOUNDS AS GPR17 ANTAGONISTS REWIND THERAPEUTICS NV (BE) 2022-12-08 WO disclosed