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SCHEMBL24697642

SCHEMBL24697642

Cc1ccc(F)c(-c2cc(S(=O)(=O)Nc3ccc(C#N)cc3F)c[nH]2)c1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ ATIC P31939 1/20 0.41
▸ CRBN Q96SW2 1/20 0.41
▸ ACLY P53396 5/20 0.39
▸ HSD11B1 P28845 2/20 0.38
▸ MOGAT2 Q3SYC2 1/20 0.37
▸ APP P05067 1/20 0.35
▸ GPR27 Q9NS67 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31085700 1.00 ATIC (0.41) ATICCRBNACLYHSD11B1MOGAT2
SCHEMBL24696659 0.93 CRBN (0.47) ATICCRBNACLYHSD11B1MOGAT2
SCHEMBL31085788 0.93 CRBN (0.47) ATICCRBNACLYHSD11B1MOGAT2
SCHEMBL31086076 0.92 ATIC (0.41) ATICCRBNACLYHSD11B1MOGAT2
SCHEMBL24697648 0.92 ATIC (0.41) ATICCRBNACLYHSD11B1MOGAT2
SCHEMBL31086045 0.91 ATIC (0.40) ATICCRBNACLYMOGAT2APP
SCHEMBL31085832 0.91 CRBN (0.42) ATICCRBNACLYHSD11B1MOGAT2
SCHEMBL31085907 0.89 ATIC (0.43) ATICCRBNACLYMOGAT2CYP3A4
SCHEMBL31086121 0.89 ATIC (0.42) ATICCRBNACLYMOGAT2APP
SCHEMBL31085862 0.88 ACLY (0.44) ATICCRBNACLYGPR27

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022254027-A1 3-PYRROLYLSULFONAMIDE COMPOUNDS AS GPR17 ANTAGONISTS REWIND THERAPEUTICS NV (BE) 2022-12-08 — — WO disclosed