Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | WDR5 | P61964 | 3/20 | 0.39 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GALK1 | P51570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698899 | 0.91 | PRKD1 (0.42) | PIK3CASMYD2NPC1RAB9AMEN1 | |
| SCHEMBL24697633 | 0.90 | PIK3CA (0.41) | PIK3CASMYD2NPC1RAB9AWDR5 | |
| SCHEMBL24697549 | 0.89 | PIK3CA (0.54) | PIK3CAGBA1MEN1KMT2A | |
| SCHEMBL24699348 | 0.87 | SUCNR1 (0.41) | PIK3CASMYD2NPC1RAB9AGBA1 | |
| SCHEMBL30016523 | 0.87 | MTOR (0.42) | PIK3CASMYD2NPC1RAB9AWDR5 | |
| SCHEMBL24698823 | 0.83 | USP30 (0.44) | PIK3CANPC1RAB9AMAPTKMT2A | |
| SCHEMBL19623865 | 0.83 | PIK3CA (0.50) | PIK3CAMAPTMEN1KMT2A | |
| SCHEMBL19623703 | 0.83 | PIK3CA (0.49) | PIK3CASMYD2PARP1MEN1KMT2A | |
| SCHEMBL24698499 | 0.82 | NPC1 (0.44) | PIK3CANPC1RAB9AMAPTMEN1 | |
| SCHEMBL19623572 | 0.82 | PIK3CA (0.49) | PIK3CAPARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |