Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | HCK | P08631 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698490 | 0.84 | ABL1 (0.39) | FAAHTGFBR1MAP3K20HSD11B1PDE10A | |
| SCHEMBL29134817 | 0.84 | ABL1 (0.39) | FAAHTGFBR1MAP3K20HSD11B1PDE10A | |
| SCHEMBL30015747 | 0.84 | ABL1 (0.39) | FAAHTGFBR1MAP3K20HSD11B1PDE10A | |
| SCHEMBL24699087 | 0.80 | DYRK1A (0.43) | TGFBR1MAP3K20IGF1RKDM4EALDH1A1 | |
| SCHEMBL24699477 | 0.77 | ALDH1A1 (0.47) | IGF1RKDM4EALDH1A1 | |
| SCHEMBL24699409 | 0.77 | KDM4E (0.40) | IGF1RKDM4EALDH1A1 | |
| SCHEMBL24697561 | 0.75 | CSNK1D (0.39) | ABL1SRCPIK3CDEGFRHCK | |
| SCHEMBL24698438 | 0.75 | ROCK2 (0.45) | PDE10AKDRPIK3CAIGF1R | |
| SCHEMBL24697795 | 0.75 | ALDH1A1 (0.40) | PIK3CAIGF1RKDM4EALDH1A1 | |
| SCHEMBL24698171 | 0.74 | ALDH1A1 (0.54) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |