Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698868 | 0.87 | PDE2A (0.38) | HRH2HRH3KARS1GBA1PDE4D | |
| SCHEMBL24698191 | 0.86 | HCRTR1 (0.36) | HRH2HRH3KARS1GBA1ALDH1A1 | |
| SCHEMBL24698467 | 0.85 | IGF1R (0.37) | HRH2HRH3KARS1GBA1ALDH1A1 | |
| SCHEMBL24698950 | 0.83 | HRH3 (0.38) | HRH2HRH3KARS1GBA1SPR | |
| SCHEMBL24698078 | 0.83 | GBA1 (0.47) | HRH2HRH3GBA1ALDH1A1KDM4E | |
| SCHEMBL24698066 | 0.83 | GBA1 (0.44) | HRH2HRH3GBA1ALDH1A1KDM4E | |
| SCHEMBL24698533 | 0.82 | GBA1 (0.46) | GBA1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL24698716 | 0.81 | HRH3 (0.36) | HRH2HRH3GBA1PDE4DALDH1A1 | |
| SCHEMBL24698712 | 0.81 | HRH3 (0.36) | HRH2HRH3GBA1PDE4DALDH1A1 | |
| SCHEMBL24698917 | 0.80 | PDE10A (0.39) | PDE4DALDH1A1PDE10AEEF2KPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |