Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698868 | 0.93 | PDE2A (0.38) | PDE10APDE2ACHEK1KDM1APIK3CA | |
| SCHEMBL24699410 | 0.85 | ALDH1A1 (0.38) | CHEK1KDM1AIKBKBPIK3CAMAPK1 | |
| SCHEMBL24698191 | 0.82 | HCRTR1 (0.36) | PDE10APDE2ACHEK1KDM1APIK3CA | |
| SCHEMBL30016847 | 0.82 | SMO (0.36) | PDE10APDE2ACHEK1KDM1APTK2 | |
| SCHEMBL24698914 | 0.82 | SMO (0.36) | PDE10APDE2ACHEK1KDM1APTK2 | |
| SCHEMBL24698426 | 0.82 | KARS1 (0.40) | PIK3CAP2RY12EEF2KALDH1A1 | |
| SCHEMBL24698467 | 0.81 | IGF1R (0.37) | PDE10APDE2AKDM1AEEF2KALDH1A1 | |
| SCHEMBL24698430 | 0.80 | PIK3CA (0.46) | PDE10AKDM1APIK3CAMAPK1MAP2K4 | |
| SCHEMBL24698078 | 0.79 | GBA1 (0.47) | CHEK1PIK3CAALDH1A1 | |
| SCHEMBL24698066 | 0.79 | GBA1 (0.44) | CHEK1KDM1APIK3CAEEF2KALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |