Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 3/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698868 | 0.90 | PDE2A (0.38) | HCRTR1HCRTR2GBA1PDE2APDE10A | |
| SCHEMBL24698467 | 0.88 | IGF1R (0.37) | HCRTR1HCRTR2GBA1PDE2APDE10A | |
| SCHEMBL24698066 | 0.86 | GBA1 (0.44) | GBA1KDM1AALDH1A1HRH2HRH3 | |
| SCHEMBL24698078 | 0.86 | GBA1 (0.47) | GBA1ALDH1A1HRH2HRH3KDM4E | |
| SCHEMBL24698952 | 0.86 | HRH2 (0.40) | HCRTR1HCRTR2GBA1PDE2APDE10A | |
| SCHEMBL24698533 | 0.85 | GBA1 (0.46) | GBA1ALDH1A1EEF2KPOLBKDM4E | |
| SCHEMBL24698774 | 0.84 | HRH3 (0.35) | GBA1PDE2APDE10AKDM1AALDH1A1 | |
| SCHEMBL24698766 | 0.84 | HRH3 (0.35) | GBA1PDE2APDE10AKDM1AALDH1A1 | |
| SCHEMBL24698917 | 0.82 | PDE10A (0.39) | PDE2APDE10AKDM1AALDH1A1EEF2K | |
| SCHEMBL24698458 | 0.81 | HRH2 (0.36) | HCRTR1HCRTR2ALDH1A1HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |