Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 4/20 | 0.40 |
| ▸ | GBA1 | P04062 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24699440 | 0.85 | PIK3CA (0.49) | KDM4EALDH1A1CNR2PIK3CAHRH2 | |
| SCHEMBL24699477 | 0.84 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24698400 | 0.81 | PIK3CA (0.49) | KDM4EALDH1A1HPGDGBA1MAPT | |
| SCHEMBL24698785 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1CNR2HPGDPIK3CA | |
| SCHEMBL24697795 | 0.79 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24699409 | 0.78 | KDM4E (0.40) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24698171 | 0.78 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDGBA1MAPT | |
| SCHEMBL24698190 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24698856 | 0.77 | PIK3CA (0.47) | KDM4EALDH1A1HPGDIGF1RGBA1 | |
| SCHEMBL24698057 | 0.77 | PIK3CA (0.44) | KDM4EALDH1A1HPGDIGF1RGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |