Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 9/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698948 | 0.89 | NISCH (0.38) | KDM4EALDH1A1IGF1RHTR2CGBA1 | |
| SCHEMBL24699001 | 0.80 | MTOR (0.36) | IGF1RINSR | |
| SCHEMBL24698495 | 0.74 | TP53 (0.44) | KDM4EALDH1A1HPGDGBA1SMN1; SMN2 | |
| SCHEMBL24698856 | 0.73 | PIK3CA (0.47) | KDM4EALDH1A1IGF1RHTR2CHPGD | |
| SCHEMBL24698050 | 0.73 | IGF1R (0.41) | KDM4EALDH1A1IGF1RHTR2CHPGD | |
| SCHEMBL24698701 | 0.73 | TDP1 (0.41) | KDM4EALDH1A1GBA1SMN1; SMN2HSD17B10 | |
| SCHEMBL24699070 | 0.73 | ALDH1A1 (0.39) | KDM4EALDH1A1IGF1RHTR2CHPGD | |
| SCHEMBL24699490 | 0.72 | KDM4E (0.38) | KDM4EALDH1A1IGF1RHTR2CHPGD | |
| SCHEMBL24698171 | 0.71 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDGBA1SMN1; SMN2 | |
| SCHEMBL24698057 | 0.70 | PIK3CA (0.44) | KDM4EALDH1A1IGF1RHTR2CHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |