Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 6/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698701 | 0.83 | TDP1 (0.41) | KDM4EALDH1A1GBA1SMN1; SMN2LMNA | |
| SCHEMBL24699489 | 0.82 | GSK3B (0.35) | ALDH1A1GSK3BLMNA | |
| SCHEMBL30015011 | 0.82 | GSK3B (0.35) | ALDH1A1GSK3BLMNA | |
| SCHEMBL24698856 | 0.81 | PIK3CA (0.47) | KDM4EALDH1A1PIK3CAIGF1RGBA1 | |
| SCHEMBL24699070 | 0.80 | ALDH1A1 (0.39) | KDM4EALDH1A1IGF1RGBA1HPGD | |
| SCHEMBL19623360 | 0.77 | PIK3CA (0.46) | KDM4EALDH1A1PIK3CAIGF1RGBA1 | |
| SCHEMBL24698057 | 0.75 | PIK3CA (0.44) | KDM4EALDH1A1PIK3CAIGF1RGBA1 | |
| SCHEMBL24697574 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1IGF1RGBA1HPGD | |
| SCHEMBL24698050 | 0.75 | IGF1R (0.41) | KDM4EALDH1A1IGF1RGBA1HPGD | |
| SCHEMBL24699355 | 0.75 | KDM4E (0.42) | KDM4EALDH1A1PIK3CAIGF1RGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |