SCHEMBL2469998

SCHEMBL2469998

COc1cc(-c2cc(N)c(Cl)c(OC(=O)O)n2)c(F)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.41
HSP90AB1 P08238 2/20 0.41
NPC1 O15118 3/20 0.35
GAA P10253 2/20 0.35
GRK6 P43250 1/20 0.35
PDCD1LG2 Q9BQ51 1/20 0.33
CD274 Q9NZQ7 1/20 0.33
MAP2 P11137 1/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
POLB P06746 1/20 0.33
STING1 Q86WV6 2/20 0.32
KMO O15229 1/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
KMT2A Q03164 1/20 0.32
LMNA P02545 1/20 0.32
TP53 P04637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
SUV39H2 Q9H5I1 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17797243 0.92 HSP90AA1 (0.34) HSP90AA1HSP90AB1NPC1GAAGRK6
SCHEMBL2467937 0.90 HSP90AA1 (0.40) HSP90AA1HSP90AB1NPC1GAAPDCD1LG2
SCHEMBL2465963 0.88 MAPK9 (0.35) HSP90AB1NPC1RAB9ASTING1KMO
SCHEMBL2469994 0.84 HSP90AA1 (0.42) HSP90AA1HSP90AB1NPC1GAAGRK6
SCHEMBL2465821 0.84 CTSA (0.37) KMT2ANPSR1
SCHEMBL2469574 0.83
SCHEMBL2462793 0.82 PDCD1LG2 (0.35) HSP90AA1HSP90AB1GAAPDCD1LG2CD274
SCHEMBL2464541 0.81 HSP90AA1 (0.35) HSP90AA1HSP90AB1NPC1GAAGRK6
SCHEMBL3332416 0.81 HSP90AA1 (0.41) HSP90AA1HSP90AB1NPC1GAAMAPT
SCHEMBL17797261 0.81 PDCD1LG2 (0.40) HSP90AA1HSP90AB1PDCD1LG2CD274KMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP claimed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed