SCHEMBL2470028

SCHEMBL2470028

COC(=O)Oc1nc(-c2ccc(Cl)c(CF)c2F)cc(N)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
CD274 Q9NZQ7 11/20 0.32
PDCD1LG2 Q9BQ51 10/20 0.32
MAPK8 P45983 2/20 0.32
MAPK9 P45984 2/20 0.32
MAPK10 P53779 2/20 0.32
SCN10A Q9Y5Y9 1/20 0.31
ALPL P05186 1/20 0.31
PDCD1 Q15116 1/20 0.31
PRKD3 O94806 1/20 0.31
MAPK1 P28482 1/20 0.31
PRKD2 Q9BZL6 1/20 0.31
KLKB1 P03952 1/20 0.31
PTGES O14684 2/20 0.31
NQO2 P16083 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2466510 0.92 MAPK9 (0.33) KDM4ECD274PDCD1LG2MAPK8MAPK9
SCHEMBL2470370 0.91 MAP4K1 (0.36) KDM4ECD274PDCD1LG2MAPK8MAPK9
SCHEMBL2466406 0.88 FFAR4 (0.32)
SCHEMBL2468807 0.87 MEP1B (0.36) KDM4ECD274PDCD1LG2SCN10AALPL
SCHEMBL2467061 0.86 SCN10A (0.33) KDM4ECD274PDCD1LG2MAPK8MAPK9
SCHEMBL2470792 0.85 KDM4E (0.31) KDM4ECD274PDCD1LG2MAPK8MAPK9
SCHEMBL2467010 0.84 CD274 (0.41) CD274PDCD1LG2PDCD1
SCHEMBL2466895 0.84 MAPK9 (0.38) KDM4ECD274PDCD1LG2MAPK8MAPK9
SCHEMBL2464652 0.84 SCN10A (0.32) KDM4ECD274PDCD1LG2MAPK8MAPK9
SCHEMBL2464045 0.84 ALPL (0.36) KDM4ECD274PDCD1LG2MAPK8MAPK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2060566-B1 Poly-substituted aryls DOW AGROSCIENCES LLC (US) 2016-06-08 EP claimed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed