Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.70 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13044618 | 0.79 | PLK1 (0.55) | HDAC6HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL16866255 | 0.77 | PLK1 (0.60) | HDAC6HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL2406942 | 0.76 | HDAC1 (0.56) | HDAC6HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL2408211 | 0.76 | EPHX2 (0.48) | HDAC6HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL2410507 | 0.76 | HDAC6 (0.44) | HDAC6HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL32681135 | 0.74 | PRMT5 (0.55) | HDAC6HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL2408145 | 0.73 | HDAC6 (0.59) | HDAC6HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL2736629 | 0.72 | KMT2A (0.56) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2408316 | 0.72 | HDAC1 (0.65) | HDAC6HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL7872561 | 0.72 | HDAC8 (1.00) | HDAC6HDAC1HDAC2HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |