Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14633541 | 0.76 | ITK (0.36) | ITKMAP3K14HTR2AWNT1 | |
| SCHEMBL2496483 | 0.75 | SYK (0.51) | KDRSYKMAPKAPK2PIM3 | |
| SCHEMBL2494409 | 0.74 | PLK2 (0.44) | ITKMAP3K14WNT1KDRSYK | |
| SCHEMBL2467117 | 0.74 | KDR (0.51) | DHFRAURKAKDRSYKAURKB | |
| SCHEMBL14633733 | 0.74 | PTGS2 (0.49) | ITKMAP2K4JAK3ROCK1 | |
| SCHEMBL14634292 | 0.74 | RIPK2 (0.44) | ITKMAP2K4CDK2 | |
| SCHEMBL785649 | 0.74 | JAK2 (0.60) | ITKHTR2AMAP2K4PDPK1RPS6KB1 | |
| SCHEMBL2471660 | 0.72 | PTK6 (0.50) | MAP2K4TGFBR1 | |
| SCHEMBL14633488 | 0.72 | GRM4 (0.49) | ITKMAP2K4ROCK1 | |
| SCHEMBL14634034 | 0.72 | EPHB4 (0.49) | MAP2K4AURKACDK2KDRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |