Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | CTSL | P07711 | 2/20 | 0.62 |
| ▸ | CTSB | P07858 | 2/20 | 0.62 |
| ▸ | CTSK | P43235 | 2/20 | 0.62 |
| ▸ | PARG | Q86W56 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 7/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394068 | 0.93 | GBA1 (0.86) | GBA1ALDH1A1PKMCTSLCTSB | |
| SCHEMBL3811045 | 0.93 | GBA1 (0.86) | GBA1ALDH1A1PKMCTSLCTSB | |
| SCHEMBL14606609 | 0.92 | GBA1 (0.84) | GBA1ALDH1A1PKMCTSLCTSB | |
| SCHEMBL4979102 | 0.92 | GBA1 (0.84) | GBA1ALDH1A1PKMCTSLCTSB | |
| SCHEMBL8396377 | 0.91 | GBA1 (0.83) | GBA1ALDH1A1PKMCTSLCTSB | |
| SCHEMBL7886816 | 0.91 | GBA1 (0.83) | GBA1ALDH1A1PKMCTSLCTSB | |
| SCHEMBL5205575 | 0.89 | GBA1 (0.79) | GBA1ALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL3851236 | 0.89 | GBA1 (0.79) | GBA1ALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL13543087 | 0.88 | GBA1 (0.78) | GBA1ALDH1A1PKMCTSLCTSB | |
| SCHEMBL9834675 | 0.88 | GBA1 (0.78) | GBA1ALDH1A1PKMCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976340-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-01-27 | — | — | EP | claimed |
| WO-2014146490-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | claimed |
| CN-104114543-B | Therapeutically active compounds and methods of use thereof | 安吉奥斯医药品有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-108912066-A | Therapeutical active compound and its application method | 安吉奥斯医药品有限公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-107417667-A | Therapeutical active compound and its application method | 安吉奥斯医药品有限公司 | 2017-12-01 | — | — | CN | disclosed |
| EP-2976340-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-01-27 | — | — | EP | disclosed |
| WO-2014146490-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014035872-A1 | TRICYCLIC ALKYNES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN | AMGEN INC. (US) | 2014-03-06 | — | — | WO | disclosed |
| EP-2488630-A1 | INDUCTION OF PLURIPOTENT CELLS | The Scripps Research Institute (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2370445-A1 | STEM CELL CULTURES | The Scripps Research Institute (US) | 2011-10-05 | — | — | EP | disclosed |
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |