Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | CTSL | P07711 | 3/20 | 0.61 |
| ▸ | CTSK | P43235 | 3/20 | 0.61 |
| ▸ | CTSB | P07858 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | PARG | Q86W56 | 1/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886816 | 1.00 | GBA1 (0.83) | GBA1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL8394068 | 0.98 | GBA1 (0.86) | GBA1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL3811045 | 0.95 | GBA1 (0.86) | GBA1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL2470122 | 0.91 | GBA1 (1.00) | GBA1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL8397048 | 0.83 | GBA1 (0.58) | GBA1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL9834675 | 0.83 | GBA1 (0.78) | GBA1KMT2AALDH1A1PKMCTSL | |
| SCHEMBL8391910 | 0.83 | GBA1 (0.58) | GBA1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL14606609 | 0.83 | GBA1 (0.84) | GBA1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL7699722 | 0.83 | KMT2A (0.68) | GBA1KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13543087 | 0.83 | GBA1 (0.78) | GBA1KMT2AALDH1A1PKMCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |