Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24706551 | 0.86 | L3MBTL1 (0.61) | L3MBTL1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23693070 | 0.82 | L3MBTL1 (0.62) | L3MBTL1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL25773741 | 0.81 | HTT (0.61) | L3MBTL1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23693073 | 0.81 | NPC1 (0.40) | L3MBTL1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4111032 | 0.80 | HTT (0.62) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL29234166 | 0.80 | HTT (0.56) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13548728 | 0.79 | L3MBTL1 (0.79) | L3MBTL1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL21322119 | 0.79 | GRM5 (0.60) | L3MBTL1NPC1MAPTGAAGRM5 | |
| SCHEMBL4814264 | 0.79 | MEN1 (0.76) | L3MBTL1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3970912 | 0.79 | MEN1 (0.76) | L3MBTL1HTTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981259-B | Novel heterocyclic compound | 豪夫迈·罗氏有限公司 | 2024-06-18 | — | — | CN | disclosed |
| US-20220396565-A1 | NOVEL HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2022-12-15 | — | — | US | disclosed |
| CN-114981259-A | Novel heterocyclic compound | 豪夫迈·罗氏有限公司 | 2022-08-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220396565-A1 | NOVEL HETEROCYCLIC COMPOUNDS | MRPL21, F12, MRPS34 | L3MBTL1 2395/4885HTT 1708/4885SMN1; SMN2 2004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.