Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514458 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1NPC1HTTMAPK1 | |
| SCHEMBL2529911 | 0.87 | CES2 (0.56) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL12596968 | 0.80 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1NPC1HTTMAPK1 | |
| SCHEMBL1765313 | 0.79 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1NPC1HTTMAPK1 | |
| SCHEMBL16213085 | 0.79 | KDM4E (0.58) | SMN1; SMN2ALDH1A1NPC1HTTMAPK1 | |
| Lithium Ion SCHEMBL1765312 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1NPC1HTTMAPK1 | |
| Lithium Ion SCHEMBL1765310 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1NPC1HTTMAPK1 | |
| SCHEMBL30666368 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1NPC1HTTMAPK1 | |
| SCHEMBL2007841 | 0.76 | CES2 (0.69) | SMN1; SMN2ALDH1A1NPC1MAPK1MEN1 | |
| SCHEMBL20267269 | 0.75 | MAPT (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287051-A1 | PROCESS FOR PREPARING AN ERK INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-08-29 | — | — | US | disclosed |
| EP-4352052-A1 | PROCESS FOR PREPARING AN ERK INHIBITOR | Otsuka Pharmaceutical Co., Ltd. (JP) | 2024-04-17 | — | — | EP | disclosed |
| CN-117881676-A | Methods for preparing ERK inhibitors | 大塚制药株式会社 | 2024-04-12 | — | — | CN | disclosed |
| WO-2022259222-A1 | PROCESS FOR PREPARING AN ERK INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022259222-A1 | PROCESS FOR PREPARING AN ERK INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2022-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287051-A1 | PROCESS FOR PREPARING AN ERK INHIBITOR | MAP3K8, MAP3K1, MAP3K6 | SMN1; SMN2 2265/4885ALDH1A1 3615/4885NPC1 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.