Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | DTYMK | P23919 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24710878 | 0.81 | GRM5 (0.33) | GPR119SPRGRM5BTKTP53 | |
| SCHEMBL24710633 | 0.76 | GPR119 (0.34) | GPR119GRM5BTKDTYMKPOLB | |
| SCHEMBL24711551 | 0.74 | GPR119 (0.37) | GPR119SPRGRM5BTKKMT2A | |
| SCHEMBL975177 | 0.74 | HPGD (0.37) | GPR119BTKMEN1KMT2A | |
| SCHEMBL14878683 | 0.72 | USP2 (0.39) | GPR119GRM5BTKMEN1KMT2A | |
| SCHEMBL12538830 | 0.71 | BTK (0.40) | GPR119GRM5BTKMEN1KMT2A | |
| SCHEMBL21258531 | 0.71 | BTK (0.36) | GPR119GRM5BTKDTYMKMEN1 | |
| SCHEMBL31555855 | 0.70 | BTK (0.47) | GPR119GRM5BTKMEN1KMT2A | |
| SCHEMBL4762097 | 0.69 | USP2 (0.41) | GPR119GRM5BTKMEN1KMT2A | |
| SCHEMBL7899134 | 0.68 | USP2 (0.38) | GPR119BTKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022258986-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | Argonaut Therapeutics Limited (GB) | 2022-12-15 | — | — | WO | disclosed |