Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1484874 | 0.83 | LMNA (0.36) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL552030 | 0.83 | LMNA (0.36) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL21725302 | 0.79 | LMNA (0.31) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL22778615 | 0.78 | NCF1 (0.42) | HTTHRH3DRD2DRD3 | |
| SCHEMBL24128021 | 0.76 | HRH3 (0.39) | LMNAHRH3DRD2DRD3 | |
| SCHEMBL22857058 | 0.76 | SMN1; SMN2 (0.39) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL3816722 | 0.75 | HRH3 (0.40) | ALDH1A1HRH3L3MBTL1 | |
| SCHEMBL12568615 | 0.74 | HRH4 (0.35) | HRH3DRD2DRD3 | |
| SCHEMBL9927933 | 0.74 | HRH4 (0.35) | HRH3DRD2DRD3 | |
| SCHEMBL25784002 | 0.74 | CYP1A2 (0.38) | HRH3DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661941-B1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2022-12-14 | — | — | EP | disclosed |