Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12102414 | 0.72 | KDM4E (0.37) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13864422 | 0.71 | HPGD (0.45) | KDM4EHTTCSNK1G1KMT2AMEN1 | |
| SCHEMBL18617868 | 0.71 | TGM2 (0.44) | KMT2AMEN1LRRK2MAPTCYP1A2 | |
| SCHEMBL14467552 | 0.71 | HPGD (0.42) | KDM4EBCHECES1GRIN2DGRIN3B | |
| SCHEMBL18567094 | 0.67 | — | — | |
| SCHEMBL11552976 | 0.67 | HTT (0.33) | BCHECES1HTTHPGDHSD17B10 | |
| SCHEMBL8507659 | 0.67 | CSNK1G1 (0.72) | CSNK1G1KMT2AMEN1POLBROS1 | |
| SCHEMBL11553132 | 0.66 | CSNK1G1 (0.40) | KDM4EBCHECES1HTTPDE3B | |
| Methane SCHEMBL5710016 | 0.64 | — | — | |
| SCHEMBL8128045 | 0.64 | POLB (0.38) | BCHECES1HTTPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2696873-B1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | US HEALTH (US) | 2022-08-03 | — | — | EP | disclosed |