Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.72 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.70 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.70 |
| ▸ | FER | P16591 | 2/20 | 0.70 |
| ▸ | LTK | P29376 | 1/20 | 0.70 |
| ▸ | CDK8 | P49336 | 1/20 | 0.70 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.62 |
| ▸ | ROS1 | P08922 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185276 | 0.84 | CSNK1G1 (1.00) | CSNK1G1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL1368292 | 0.83 | LRRK2 (1.00) | CSNK1G1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL2420711 | 0.83 | LRRK2 (0.90) | CSNK1G1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL366728 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL6299954 | 0.81 | LRRK2 (0.95) | CSNK1G1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL8204226 | 0.81 | CHEK1 (0.72) | CSNK1G1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL27980501 | 0.79 | LRRK2 (0.82) | CSNK1G1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL9653269 | 0.78 | ACVR1 (0.65) | CSNK1G1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL16306322 | 0.78 | ACVR1 (0.65) | CSNK1G1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL3408793 | 0.77 | LRRK2 (0.69) | CSNK1G1ACVR1LRRK2PDGFRAFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968478-A | DIBENZOTHIEPINE AS NEUROTRANSMITTERS AND FOR DRUG SCREENING AND TREATMENT OF SCHIZOPHRENIA | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-10-19 | — | — | US | disclosed |