Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306341 | 0.92 | ADORA1 (0.42) | ADORA1MAP4K4KDM1ARAB9ANPC1 | |
| SCHEMBL18306437 | 0.85 | KDM1A (0.46) | ADORA1MAP4K4KDM1AROCK1 | |
| SCHEMBL17177311 | 0.82 | BTK (0.41) | ADORA1ALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL17177309 | 0.82 | DHODH (0.33) | ADORA1ADORA2A | |
| SCHEMBL18306366 | 0.81 | FYN (0.36) | ADORA1MAP4K4HPGDSMN1; SMN2FYN | |
| SCHEMBL17177310 | 0.80 | ADORA1 (0.42) | ADORA1MAP4K4RAB9ANPC1ALDH1A1 | |
| SCHEMBL18306300 | 0.76 | USP7 (0.34) | KDM1AALDH1A1HSD17B10KMT2ATGFBR1 | |
| SCHEMBL18306348 | 0.75 | RPS6KA3 (0.37) | MAP4K4ALDH1A1TGFBR1MAPK14NTRK1 | |
| SCHEMBL15636773 | 0.75 | DYRK1A (0.44) | ADORA1MAP4K4KDM1ATGFBR1MAPK14 | |
| SCHEMBL18306367 | 0.73 | AURKA (0.37) | MAP4K4TGFBR1TGFBR2ABL1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | disclosed |