Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716156 | 0.92 | ADORA1 (0.41) | ADORA1MAP4K4KDM1AKMT2ARAB9A | |
| SCHEMBL18306366 | 0.90 | FYN (0.36) | ADORA1PTGS1PTGS2MAP4K4FYN | |
| SCHEMBL18306437 | 0.86 | KDM1A (0.46) | ADORA1MAP4K4KDM1AROCK1 | |
| SCHEMBL18306300 | 0.84 | USP7 (0.34) | PTGS1PTGS2KDM1AKMT2APIM1 | |
| SCHEMBL18306348 | 0.83 | RPS6KA3 (0.37) | PTGS1PTGS2MAP4K4NTRK1CSF1R | |
| SCHEMBL17177311 | 0.83 | BTK (0.41) | ADORA1PTGS1PTGS2KMT2AFYN | |
| SCHEMBL18306342 | 0.81 | KMT2A (0.40) | ADORA1MAP4K4KMT2ALCKFGFR1 | |
| SCHEMBL17177310 | 0.81 | ADORA1 (0.42) | ADORA1MAP4K4KMT2ARAB9ANPC1 | |
| SCHEMBL18306343 | 0.78 | ABL1 (0.36) | KMT2AABL1FYNPDGFRBFGFR1 | |
| SCHEMBL18306367 | 0.74 | AURKA (0.37) | PTGS1PTGS2MAP4K4ABL1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MIDCAP FINANCIAL TRUST | 2017-11-30 | — | — | US | disclosed |
| US-9518040-B2 | GDF-8 inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2016-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342048-A1 | GDF-8 Inhibitors | MSTN, MYOF, CXCL8 | ADORA1 1930/4885PTGS1 762/4885PTGS2 1658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.