Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638693 | 0.82 | QPCT (0.51) | MAPK14BCHEACHETGFBR1 | |
| SCHEMBL15638586 | 0.81 | TGFBR1 (0.62) | TGFBR1CSNK1DCDC7 | |
| SCHEMBL15639158 | 0.81 | MAP2K4 (0.49) | MAPK14TGFBR1CSNK1DCSNK1E | |
| SCHEMBL15640161 | 0.81 | FGFR1 (0.51) | BCHEACHETGFBR1 | |
| SCHEMBL2187789 | 0.81 | ADORA1 (0.55) | BCHEACHETGFBR1PTGS1PTGS2 | |
| SCHEMBL15639333 | 0.79 | TGFBR1 (0.64) | MAPK14BCHEACHETGFBR1PTGS1 | |
| SCHEMBL30117529 | 0.79 | TGFBR1 (0.64) | MAPK14BCHEACHETGFBR1PTGS1 | |
| SCHEMBL15638336 | 0.78 | NPC1 (0.47) | MAPK14BCHEACHETGFBR1CSNK1D | |
| SCHEMBL15640109 | 0.78 | MAPK14 (0.43) | MAPK14BCHEACHETGFBR1PTGS1 | |
| SCHEMBL15637987 | 0.78 | MAPK14 (0.43) | MAPK14BCHETGFBR1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | disclosed |