Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.48 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | NPM1 | P06748 | 1/20 | 0.42 |
| ▸ | FES | P07332 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29869206 | 1.00 | ALK (0.52) | ALKCDK7CDK9MAP4K1INSR | |
| SCHEMBL29869150 | 0.91 | MAP4K1 (0.50) | ALKMAP4K1PTK2AURKB | |
| SCHEMBL24716308 | 0.91 | MAP4K1 (0.50) | ALKMAP4K1PTK2AURKB | |
| SCHEMBL24716051 | 0.89 | MAP4K1 (0.49) | ALKCDK7CDK9MAP4K1AURKB | |
| SCHEMBL24716360 | 0.84 | ALK (0.73) | ALKINSRKCNH2MET | |
| SCHEMBL24716300 | 0.84 | MAP4K1 (0.49) | ALKMAP4K1EGFR | |
| SCHEMBL24716054 | 0.80 | MAP4K1 (0.49) | MAP4K1EGFR | |
| SCHEMBL24716377 | 0.75 | ALK (0.60) | ALKCDK7CDK9MAP4K1INSR | |
| SCHEMBL24716309 | 0.73 | ALK (0.58) | ALKMAP4K1AURKB | |
| SCHEMBL24716365 | 0.73 | AXL (0.73) | ALKMAP4K1INSRIGF1RAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848103-A | High activity HPK1 kinase inhibitors | 杭州阿诺生物医药科技有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |