Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29869150 | 1.00 | MAP4K1 (0.50) | MAP4K1EPHB4AURKAAURKBALK | |
| SCHEMBL24716051 | 0.91 | MAP4K1 (0.49) | MAP4K1EPHB4AURKAAURKBALK | |
| SCHEMBL24716298 | 0.91 | ALK (0.52) | MAP4K1AURKBALKPTK2 | |
| SCHEMBL29869206 | 0.91 | ALK (0.52) | MAP4K1AURKBALKPTK2 | |
| SCHEMBL24716377 | 0.83 | ALK (0.60) | MAP4K1AURKAAURKBALKAXL | |
| SCHEMBL24716300 | 0.82 | MAP4K1 (0.49) | MAP4K1AURKAALKJAK2JAK3 | |
| SCHEMBL24716054 | 0.82 | MAP4K1 (0.49) | MAP4K1AURKAJAK2JAK3 | |
| SCHEMBL24716309 | 0.75 | ALK (0.58) | MAP4K1AURKAAURKBALKAXL | |
| SCHEMBL24716365 | 0.75 | AXL (0.73) | MAP4K1AURKAAURKBALKAXL | |
| SCHEMBL24716360 | 0.75 | ALK (0.73) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848103-A | High activity HPK1 kinase inhibitors | 杭州阿诺生物医药科技有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |