Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24718263 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KCNH2CACNA1IKMT2ANPC1 | |
| SCHEMBL24718672 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KCNH2CACNA1IKMT2ANPC1 | |
| SCHEMBL24718842 | 0.94 | ALDH1A1 (0.47) | ALDH1A1KCNH2CACNA1IKMT2ANPC1 | |
| SCHEMBL24718261 | 0.85 | P2RX7 (0.41) | ALDH1A1NPC1P2RX7TMPRSS4 | |
| SCHEMBL24718648 | 0.85 | TEAD1 (0.52) | ALDH1A1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL24718303 | 0.85 | TEAD1 (0.52) | ALDH1A1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL24718257 | 0.85 | TEAD1 (0.52) | ALDH1A1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL24718661 | 0.79 | P2RX7 (0.49) | ALDH1A1KCNH2CACNA1IKMT2ANPC1 | |
| SCHEMBL24718841 | 0.79 | P2RX7 (0.49) | ALDH1A1KCNH2CACNA1IKMT2ANPC1 | |
| SCHEMBL24718666 | 0.79 | P2RX7 (0.49) | ALDH1A1KCNH2CACNA1IKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | UNITED STATES GOVERNMENT | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | EED, EZH2, ELP1 | ALDH1A1 1312/4885KCNH2 4627/4885CACNA1I 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.