Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amitraz SCHEMBL19312984 | 1.00 | CYP3A4 (1.00) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| Amitraz SCHEMBL37309 | 1.00 | CYP3A4 (1.00) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| Amitraz SCHEMBL3957192 | 1.00 | CYP3A4 (1.00) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| Amitraz SCHEMBL2471817 | 1.00 | CYP3A4 (1.00) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| Amitraz SCHEMBL1765794 | 1.00 | CYP3A4 (1.00) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| Amitraz SCHEMBL13346111 | 1.00 | CYP3A4 (1.00) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| Amitraz SCHEMBL29370387 | 1.00 | CYP3A4 (1.00) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| Amitraz SCHEMBL890417 | 0.98 | CYP3A4 (0.96) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| SCHEMBL13346107 | 0.91 | CYP3A4 (0.83) | CYP3A4ADRA2AALDH1A1KDM4ELMNA | |
| Amitraz SCHEMBL9026554 | 0.91 | CYP3A4 (0.83) | CYP3A4ADRA2AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364147-A2 | COMPOSITIONS COMPRISING 1-ARYLPYRAZOLE ALONE OR IN COMBINATION WITH FORMAMIDINE FOR THE TREATMENT OF PARASITIC INFECTION | Merial Limited (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010059529-A2 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND/OR A FORMAMIDINE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2010-05-27 | — | — | WO | disclosed |