Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.52 |
| ▸ | ATR | Q13535 | 10/20 | 0.47 |
| ▸ | MTOR | P42345 | 7/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 7/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 7/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22163221 | 1.00 | PIK3CA (0.52) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL22163219 | 1.00 | PIK3CA (0.52) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL21262049 | 0.82 | PIK3CD (0.52) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL22578850 | 0.82 | PIK3CD (0.52) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL25275495 | 0.82 | PIK3CD (0.58) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL22116376 | 0.81 | ATR (0.48) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL22116377 | 0.81 | ATR (0.48) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL3081642 | 0.79 | MTOR (0.54) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL3083698 | 0.78 | PDPK1 (0.58) | PIK3CAPIK3CDATRMTORPDCD1 | |
| SCHEMBL11634928 | 0.78 | MTOR (0.54) | PIK3CAPIK3CDATRMTORPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588471-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | PIK3CA 28/4885PIK3CD 24/4885ATR 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.